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Long intergenic non-protein coding RNA 1063 (LINC01063)
- Target
- LINC01063
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding RNA, Other (does not fit classic families such as receptors, enzymes, transporters)
01
Overview
Long intergenic non-protein coding RNA 1063 (LINC01063) is a non-coding RNA gene that does not encode a protein but produces a transcript involved in the regulation of gene expression, especially by acting as a molecular sponge for microRNAs (notably miR-5194). LINC01063 is significantly upregulated in melanoma, promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of melanoma cells via the miR-5194/SOX12 axis, and may function as a prognostic or therapeutic biomarker in cancer, although no interacting drugs have been characterized for this target to date[1][2][3].
- Other names
- lncRNA LINC01063ENSG00000232065
02
Mechanism of action
miRNA sponge—acts as a competing endogenous RNA to sequester miR-5194, leading to upregulation of target genes (e.g., SOX12)
03
Biological functions
Gene regulation (as a competing endogenous RNA or miRNA sponge)Regulation of cell proliferationRegulation of cell migration and invasionEpithelial-mesenchymal transition (EMT)Other (RNA-based regulation)
04
Disease associations
Cancer (specifically melanoma; potentially other cancers based on lncRNA literature)Other (may be implicated in gene expression dysregulation)
05
Safety considerations
Potential off-target effects in therapeutic targeting, common to RNA-based approachesNeed for specificity to avoid unintended gene regulation
06
Biomarkers
Prognostic biomarker: Higher LINC01063 expression correlates with advanced and metastatic melanoma
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