Long intergenic non-protein coding RNA 1085 (LINC01085)

Long intergenic non-protein coding RNA 1085 (LINC01085) is a long non-coding RNA gene located on chromosome 4 and categorized as a lncRNA, meaning it is transcribed into RNA but not translated into protein. It is implicated in the modulation of drug resistance, particularly in hormone-independent prostate cancer, where its expression modulates interactions between TANK-binding kinase 1 (TBK1) and glycogen synthase kinase 3β (GSK3β), thereby affecting immune pathways and response to docetaxel chemotherapy. LINC01085’s dysregulation may serve as a biomarker for chemoresistance in prostate cancer, and its overexpression enhances the efficacy of immune checkpoint blockade therapies. It is not classified as a traditional therapeutic target like a receptor, enzyme, or transporter, but plays a functional regulatory role in cancer cell signaling. No direct drugs are known to target LINC01085, and its clinical utility as a drug target remains investigational.

Other names

ENSG00000248698KLF17P2152742 (NCBI Gene)GC04P014114 (previous IDs and database references)

Not a direct drug target, but overexpression modulates docetaxel response by interfering with TBK1 dimerization and downstream immune signaling pathways (STING/MAVS)