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Long intergenic non-protein coding RNA 1091 (LINC01091) is a human long intergenic non-coding RNA (lincRNA) transcribed from the LINC01091 gene. LINC01091 participates in both transcriptional and post-transcriptional regulation of gene expression through mechanisms such as chromatin remodeling, histone modification, and interactions with microRNAs. Its dysregulation has been implicated in various diseases, notably certain cancers such as pancreatic adenocarcinoma, where its expression differs between tumor and non-tumor samples, suggesting involvement in disease pathogenesis. LINC01091 may also contribute to regulatory networks affecting processes like epithelial-to-mesenchymal transition, metastasis, and potentially male infertility, indicating a broader functional spectrum typical for lincRNAs. However, there is currently no evidence that LINC01091 serves as a direct therapeutic target or interacts with known drugs[1][4][3].
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