Long intergenic non-protein coding RNA 1093 (LINC01093)

Long intergenic non-protein coding RNA 1093 (LINC01093) is a human long non-coding RNA (lncRNA) that does not encode a protein but regulates gene expression through interactions with microRNAs and transcription factors[3]. LINC01093 acts mainly as a competing endogenous RNA (ceRNA), sponging specific microRNAs and thereby modulating the expression of target genes. In normal human tissues, its expression is largely confined to the liver, and it is significantly downregulated in hepatocellular carcinoma (HCC) where lower expression is associated with poor prognosis[1][3][6]. Functional studies indicate LINC01093 can suppress hepatocyte apoptosis and promote cell proliferation in liver contexts by inhibiting ICAM-1-mediated NF-κB signaling; its overexpression also represses elements of hepatic inflammation and fibrosis[2]. In cancer biology, particularly HCC and non-small cell lung cancer (NSCLC), LINC01093 modifies cell proliferation and invasiveness, partly through regulation of Akt and NF-κB pathways[4]. It has been proposed as a diagnostic and prognostic biomarker for HCC[5], but is not currently the target of approved therapeutics. No direct drug interactions or specific mechanisms of action for drug modulation of LINC01093 have been reported.

Other names

LINC01093