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Long intergenic non-protein coding RNA 1104 (LINC01104)
- Target
- LINC01104
- Molecular classification
- Long intergenic non-coding RNA (lincRNA), Long non-coding RNA (lncRNA; a broader class)
01
Overview
Long intergenic non-protein coding RNA 1104 (LINC01104) is a human long intergenic non-coding RNA gene located on chromosome 2q11.2. It belongs to a class of non-coding RNAs that do not overlap coding genes and do not translate into proteins. LincRNAs, including LINC01104, are implicated in diverse cellular functions such as regulation of chromatin structure, transcription, and cell cycle control through non-coding RNA mechanisms. While many lincRNAs have emerging roles in development, aging, and disease, specific roles for LINC01104 remain under investigation. There are no reported drugs, known direct disease mechanisms, or clinical biomarker uses for LINC01104, and it is not considered a direct therapeutic target at present.
- Other names
- LINC01104Long intergenic non-protein coding RNA 1104
02
Mechanism of action
None applicable. No drugs targeting LINC01104 or its gene products are known, thus no mechanism of action is established.
03
Biological functions
Regulation of chromatin topology (remodel chromatin, regulate genome architecture)Regulation of gene expression (transcriptional regulation, enhancer-like activities)RNA stabilizationCell cycle regulation, cell-size control (based on broader lincRNA functional studies)Fine-tuning of neighboring gene expression (often with tissue specificity)Potential participation in epigenetic regulation
04
Disease associations
Cancer (many lincRNAs are being studied for roles in oncogenesis, but a direct role of LINC01104 in cancer or other diseases is undetermined)Possible involvement in muscle aging and grip strength, based on association studiesOther disease roles are speculative as functional characterization of LINC01104 is incomplete
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