Long intergenic non-protein coding RNA 1108 (LINC01108)

Long intergenic non-protein coding RNA 1108 (LINC01108) is a member of the long non-coding RNA (lncRNA) family, specifically categorized as an intergenic lncRNA. LINC01108 does not encode a protein but may regulate gene expression through mechanisms characteristic of lncRNAs, such as chromatin modification, modulation of transcription, and acting as molecular scaffolds or decoys for transcriptional regulators. The gene is located on human chromosome 6p23 (6:14280127-14285454), with Ensembl ID ENSG00000226673 and NCBI Gene ID 102216342. LINC01108 has associations reported in genome-wide studies with conditions including major depressive disorder and bone osteosarcoma; however, its direct mechanistic role in these diseases is not well characterized. Current literature and databases do not identify it as a direct therapeutic target (such as a receptor, transporter, or enzyme), nor are there known drugs or biomarkers specifically interacting with or driven by LINC01108. Notes: - There is no evidence that LINC01108 is a current direct therapeutic target or that drugs exist to target this RNA. - LncRNA-ES1 appears to be an alias, but most evidence refers to pluripotency-associated lncRNAs in the context of stem cells; connection to LINC01108 is not fully established beyond nomenclature. - Its functions and disease roles are inferred by analogy to the lncRNA family rather than by direct mechanistic studies for this specific gene.

Other names

LncRNA-ES1lncRNA embryonic stem cell 1LincRNA-ES1