Target intelligence / Profile preview

Long intergenic non-protein coding RNA 1122 (LINC01122)

Target
LINC01122
Molecular classification
Long non-coding RNA, Long intergenic non-coding RNA (lincRNA), Non-coding RNA
01

Overview

Long intergenic non-protein coding RNA 1122 (LINC01122) is a long intergenic non-coding RNA transcript, typically not translated into protein, and located predominantly in the cytoplasm[4]. Like other lincRNAs, LINC01122 is involved in the regulation of gene expression at various levels, including acting as a competing endogenous RNA (ceRNA) that can bind and “sponge” microRNAs, thereby modulating the expression of protein-coding targets such as TPD52[4]. LINC01122 has been identified as a prognostic marker in prostate adenocarcinoma, where its dysregulation forms part of the LINC01122/TPD52 axis, influencing tumor biology and patient outcomes. While its exact molecular roles remain incompletely characterized, LINC01122 is a representative of a growing class of lincRNAs implicated in gene regulation and cancer biology[1][3][4]. No known drugs currently target LINC01122 directly, and its role is primarily studied as a biomarker or regulatory molecule rather than as a direct therapeutic target.

Other names
FLJ30838AC007092.1LINC01793long intergenic non-protein coding RNA 1793LINC01122
02

Biological functions

Regulation of gene expression (post-transcriptional, epigenetic, RNA-level)Competing endogenous RNA (ceRNA) activityRegulation via miRNA sponging (e.g., hsa-miR-34c-5p, hsa-miR-449a)
03

Disease associations

Cancer (e.g., prostate adenocarcinoma (PRAD))
04

Safety considerations

Limited clinical validation; the biomarker potential requires further verification in diverse patient cohorts for clinical implementation
05

Biomarkers

LINC01122/TPD52 axis as a prognostic biomarker in prostate adenocarcinoma (PRAD)

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