Long intergenic non-protein coding RNA 1124 (LINC01124)

Long intergenic non-protein coding RNA 1124 (LINC01124) is a long noncoding RNA gene located at chromosome 2q31.1 and typically contains a single exon[3]. LINC01124 is part of the lncRNA class, which do not encode proteins but regulate gene expression mainly through interactions with microRNAs and other biomolecules. Studies have shown LINC01124 is upregulated in several tumor types, such as hepatocellular carcinoma and colon cancer, where its overexpression promotes cell proliferation, migration, and invasion by acting as a competing endogenous RNA (ceRNA) that "sponges" microRNAs such as miR-1247-5p and miR-654-5p, leading to increased expression of oncogenic proteins like FOXO3 and HAX-1[1][2][4]. Conversely, LINC01124 appears downregulated in non-small cell lung cancer, where enforced expression suppresses proliferation and migration, indicating a potential tumor suppressor role in this context[3]. Its dysregulation in cancers makes it a candidate biomarker and possible therapeutic target in oncology, though no drugs directly target LINC01124 to date[1][2][3][4].

Other names

LINC01124long noncoding RNA 01124long non-coding RNA 01124

Sponges microRNAs (e.g., miR-1247-5p in hepatocellular carcinoma, miR-654-5p in colon cancer) and regulates gene expression via ceRNA mechanism.