Long intergenic non-protein coding RNA 1128 (LINC01128)

Long intergenic non-protein coding RNA 1128 (LINC01128) is a human long non-coding RNA (lncRNA) gene located on chromosome 1[1][5][8][10]. As a member of the lncRNA class, LINC01128 does not encode proteins but instead modulates cellular processes primarily at the level of gene expression. It acts through mechanisms such as sponging microRNAs (e.g., miR-27b-3p, miR-299-3p, miR-561-5p, miR-142-5p) and interacting with protein complexes, influencing biological functions like cell proliferation, apoptosis, inflammation, and pyroptosis[1][2][3][4][6][7]. Dysregulation of LINC01128 expression has been described in various cancers, including prostate, pancreatic, colorectal, osteosarcoma, glioma, and multiple myeloma, with both oncogenic and tumor-suppressive roles depending on disease context[2][3][4][8]. It functions as a molecular sponge, regulating the activity of oncogenes and tumor suppressor genes, and its expression patterns have been linked to prognosis in certain cancers (notably multiple myeloma and prostate cancer)[2][3][4]. Although it is widely studied for its regulatory roles in cancer biology, there are currently no known direct therapeutic drugs targeting this non-coding RNA, nor established mechanisms of action for pharmacological modulation[2][3][5][8].

Other names

RP11-206L10.11FAM87BHSALNG0000041LOC100506327NONHSAG000047