Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Long intergenic non-protein coding RNA 115 (LINC00115)
- Target
- LINC00115
- Molecular classification
- Long non-coding RNA, lncRNA, non-protein coding RNA
01
Overview
Long intergenic non-protein coding RNA 115 (LINC00115), also known as FLJ22639, is a long non-coding RNA (lncRNA) that functions as a gene regulator by acting as a molecular sponge for specific microRNAs (such as miR-489-3p and miR-200 family), thereby derepressing oncogenic pathways such as PI3K/AKT/mTOR, ZEB1, and ZNF596 signaling. LINC00115 is highly expressed in multiple human cancers, where its upregulation correlates with increased proliferation, migration, invasion, metastatic capabilities, and poor patient prognosis. Knockdown of LINC00115 suppresses these malignant properties in cancer models, supporting its characterization as an oncogenic lncRNA and an emerging therapeutic target in oncology.
- Other names
- FLJ22639NCRNA00115LINC00115GC01M000761GC01M000826GC01M000830ENSG00000225880HGNC:26211
02
Mechanism of action
Acts as a competing endogenous RNA (ceRNA) sequestering microRNAs (miRNAs), leading to upregulation of target genes (e.g., PFKFB2, ZEB1, ZNF596). Modulation of PI3K/AKT/mTOR pathway (colorectal cancer).
03
Biological functions
miRNA inhibitor activity/miRNA sponge (e.g., miR-489-3p, miR-200b/c)Regulation of gene silencingRegulation of cell proliferation, migration, and invasionPromotion of metastasisRegulation of stem cell growth/self-renewal (glioma CSCs)
04
Disease associations
Cancer (including breast, colorectal, glioblastoma, retinoblastoma, cervical, bladder, lung adenocarcinoma, colon adenocarcinoma)Metastasis promotion in cancerAssociated with poor prognosis and aggressive tumor phenotypes
05
Safety considerations
No specific safety concerns are reported, but therapeutic targeting may affect gene expression networks broadly due to lncRNA’s central regulatory roles; off-target effects and general challenges of lncRNA targeting apply.
06
Biomarkers
Elevated LINC00115 expression is a biomarker of aggressive tumor behavior and poor prognosis in some cancers (e.g., retinoblastoma, glioblastoma, breast, colorectal)
Beyond the preview
Go deeper on Long intergenic non-protein coding RNA 115 (LINC00115).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Long intergenic non-protein coding RNA 115 (LINC00115).