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Long intergenic non-protein coding RNA 1184 (SLC12A2-DT)

Target
SLC12A2-DT
Molecular classification
Long non-coding RNA (lncRNA), Long intergenic non-protein coding RNA (lincRNA)
01

Overview

SLC12A2-DT is a human long non-coding RNA gene, classified as a divergent transcript and particularly known as LINC01184. Unlike protein-coding genes, it produces a non-protein coding RNA transcript approximately 2977 nucleotides in length[2]. SLC12A2-DT belongs to the class of long intergenic non-protein coding RNAs (lincRNAs), which regulate gene expression and cellular responses[1][6][2][8]. SLC12A2-DT is identified as a locus associated with risk of skin and soft tissue infections, and its expression patterns may change under cellular stress such as bacterial infection or certain cancers[3][2][6][7]. Although not a canonical drug target, its regulatory roles and disease associations suggest it may serve as a biomarker for infection or cancer, but no established therapeutic interventions directly target this molecule[2][6][3].

Other names
SLC12A2 divergent transcriptFLJ33630LINC01184long intergenic non-protein coding RNA 1184SLC12A2-DT
02

Biological functions

Regulation of gene expressionCellular stress response (expression changes following stress and infection)Potential involvement in transcriptional regulation (general for lincRNAs, not specific for SLC12A2-DT yet)
03

Disease associations

Risk locus for skin and soft tissue infections identified by GWAS (as LINC01184/SLC12A2)Implicated in colorectal cancer (role explored but not fully defined)Putative biomarker for cellular stress response and infection
04

Biomarkers

Response to bacterial infection: Expression decreases after exposure to lipopolysaccharide (LPS), suggesting utility as a marker of cellular bacterial stress responseExpression changes in cancer and infection contexts may serve as potential diagnostic/prognostic biomarkers

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