Long intergenic non-protein coding RNA 1191 (LINC01191)

Long intergenic non-protein coding RNA 1191 (LINC01191) is a non-coding RNA gene located on human chromosome 2. It functions as an important regulatory molecule in cancer progression through multiple mechanisms, primarily acting as a competitive endogenous RNA (ceRNA) by binding to microRNAs and relieving their inhibitory effects on target mRNAs[1][2]. LINC01191 is overexpressed in various cancer types and significantly correlates with cancer development, poor prognosis, tumor progression, metastasis, and chemotherapy resistance[2]. The molecule regulates key cellular processes including proliferation, migration, invasion, apoptosis, and epithelial-mesenchymal transition through complex signaling pathways involving microRNA sponging, transcription factor interactions, and epigenetic modifications[2]. Its widespread involvement in cancer biology makes it a promising candidate for both diagnostic biomarker applications and therapeutic targeting, though current research is primarily at the experimental stage with limited clinical translation[2].

Other names

VINlnc-ACTR3virus inducible lincRNA

Competitive endogenous RNA (ceRNA) mechanism by sponging microRNAs, Direct binding to transcription factors, Protein recruitment for epigenetic modifications, Translation regulation through UTR interactions