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Long intergenic non-protein coding RNA 1213 (LINC01213)
- Target
- LINC01213
- Molecular classification
- Long non-coding RNA, Long intergenic non-protein coding RNA
01
Overview
Long intergenic non-protein coding RNA 1213 (LINC01213) is a long non-coding RNA located in intergenic regions, not overlapping with protein-coding genes. It does not encode a protein but functions in gene regulatory mechanisms. LINC01213 has been found upregulated in several cancer types, notably in castration-resistant prostate cancer, where it is transferred via exosomes and promotes androgen independence by activating the Wnt/β-catenin signaling pathway. Its elevated expression correlates with a worse prognosis in prostate cancer, suggesting its potential as a therapeutic target and biomarker for disease progression[1][2].
- Other names
- LINC01213LOC105374313
02
Mechanism of action
Modulation of Wnt/β-catenin pathway activity, Regulation through exosomal transfer in tumor microenvironment
03
Biological functions
Regulation of cell proliferationRegulation of cell cycleModulation of Wnt/β-catenin signalingOncogenic regulationRegulation of androgen independence in prostate cancer
04
Disease associations
CancerProstate cancer (castration-resistant prostate cancer, CRPC)Potential role in breast cancer
05
Safety considerations
none reportedgeneral lncRNA challenges such as off-target effects in RNA-targeted therapy
06
Biomarkers
Elevated LINC01213 expression correlates with poor prognosis in prostate cancerImplicated as a possible biomarker for CRPC
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