Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1255 (LINC01255)
- Target
- LINC01255
- Molecular classification
- Long non-coding RNA, Long intergenic non-coding RNA (lincRNA)
01
Overview
Long intergenic non-protein coding RNA 1255 (LINC01255) is a long intergenic non-coding RNA (lincRNA) gene that does not encode a protein but functions as a regulatory RNA molecule. LINC01255 is highly expressed in bone marrow cells of patients with acute myeloid leukemia (AML) and its elevated expression is correlated with poor prognosis in AML. Functional studies have shown that LINC01255 interacts with BMI1 protein and represses the transcription of MCP-1, leading to activation of the p53-p21 pathway; this results in inhibition of senescence in human mesenchymal stromal cells and promotes proliferation of AML cells. LINC01255 is not a protein receptor, enzyme, or transporter, but part of the large, diverse family of long non-coding RNAs involved in gene expression regulation, chromatin remodeling, and cell state maintenance. There is currently no direct evidence for drugs targeting LINC01255, nor is it established as a conventional therapeutic target.
- Other names
- LINC01255
02
Biological functions
Regulation of gene transcriptionInhibition of cell senescenceRegulation of cell proliferation
03
Disease associations
Cancer (notably acute myeloid leukemia, AML)Other (potential roles in other malignancies, but limited evidence specific for LINC01255)
04
Biomarkers
High LINC01255 expression is associated with poor survival in acute myeloid leukemia (AML) patients
Beyond the preview
Go deeper on Long intergenic non-protein coding RNA 1255 (LINC01255).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Long intergenic non-protein coding RNA 1255 (LINC01255).