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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1281 (LINC01281)
- Target
- LINC01281
- Molecular classification
- Other (Long non-coding RNA / lncRNA)
01
Overview
Long intergenic non-protein coding RNA 1281 (LINC01281) is a functionally uncharacterized long non-coding RNA (lncRNA) gene that does not encode a protein but regulates gene expression at the transcriptional and possibly post-transcriptional level[1][5]. It has been identified as part of an lncRNA signature associated with the prognosis of head and neck squamous cell carcinoma (HNSCC) and has been implicated as a potential biomarker for cancer outcomes[2]. Specifically, low expression of LINC01281 correlates with poor survival in certain cancers, and it has been reported to modulate overall survival in laryngeal squamous cell carcinoma by activating Wnt signaling pathways involved in cellular proliferation, migration, and apoptosis[2]. LINC01281 currently lacks evidence as a direct therapeutic target or drug-binding molecule but serves as a potential prognostic biomarker in oncology research[2][5].
- Other names
- LINC01281
02
Biological functions
Regulation of gene expressionModulation of cell proliferationModulation of cell migrationInvolvement in apoptosisPossible role in signaling pathways (e.g., Wnt signaling)
03
Disease associations
CancerPossible biomarker/prognostic indicator in cancer (specifically head and neck squamous cell carcinoma and laryngeal squamous cell carcinoma)
04
Biomarkers
Prognostic biomarker for head and neck squamous cell carcinoma (HNSCC)Potentially influences overall survival in laryngeal squamous cell carcinoma
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