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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1291 (LINC01291)
- Target
- LINC01291
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA), Other
01
Overview
Long intergenic non-protein coding RNA 1291 (LINC01291) is a cytoplasmic long non-coding RNA predominantly upregulated in melanoma tissues and cell lines. It acts as a competing endogenous RNA (ceRNA) by sponging microRNA-625-5p (miR-625-5p), thereby promoting insulin-like growth factor 1 receptor (IGF-1R) expression, which drives melanoma cell proliferation, migration, invasion, and chemoresistance to cisplatin, while inhibiting apoptosis and cell cycle arrest. Silencing LINC01291 suppresses tumor growth and progression, suggesting a pathogenic role in melanoma and indicating its potential as a diagnostic biomarker and therapeutic target.
- Other names
- TCONS_00002938AC104135.4LINC01293long intergenic non-protein coding RNA 1293
02
Mechanism of action
Functions as a molecular sponge for miR-625-5p, indirectly maintaining insulin-like growth factor 1 receptor (IGF-1R) expression
03
Biological functions
Competing endogenous RNA function (miRNA sponge)Regulation of cell proliferationRegulation of apoptosisRegulation of cell migrationRegulation of cell invasionChemoresistance modulationRegulation of cell cycle
04
Disease associations
Cancer (Melanoma)Other
05
Safety considerations
Potential off-target effects when targeting lncRNAsBiological complexity and context-specificity of lncRNA function
06
Interacting drugs
Cisplatin
07
Biomarkers
LINC01291 expression as a potential diagnostic biomarkermiR-625-5p and IGF-1R levels in the LINC01291/miR-625-5p/IGF-1R pathway
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