Long intergenic non-protein coding RNA 1303 (LINC01303)

Long intergenic non-protein coding RNA 1303 (LINC01303) is a non-coding RNA transcript that does not encode a protein, but instead regulates gene expression through multiple mechanisms, including acting as a molecular sponge for specific microRNAs (such as miR-101-3p and miR-200c). LINC01303 is significantly upregulated in both gastric cancer and laryngeal squamous cell carcinoma, where it promotes cell proliferation, migration, invasion, and cancer progression. In gastric cancer, LINC01303 functions as a competing endogenous RNA to regulate the expression of EZH2 by sponging miR-101-3p. In laryngeal squamous cell carcinoma, LINC01303 participates in tumorigenesis through the miR-200c/TIMP2 axis, driving proliferation and metastasis. Knockdown or inhibition of LINC01303 results in decreased tumor growth, invasion, and increased apoptosis, highlighting its role as a potential therapeutic target in oncology. LINC01303 belongs to the long intergenic non-coding RNA class, a group of RNAs longer than 200 nucleotides, transcribed from intergenic regions of the genome, with important roles in chromatin architecture, transcriptional regulation, and post-transcriptional gene control.

Other names

LINC01303

Drugs or molecules targeting LINC01303 would act by modulating its interaction with microRNAs (such as miR-101-3p or miR-200c) and downstream effectors (e.g., TIMP2, EZH2)