Long intergenic non-protein coding RNA 1322 (LINC01322)

LINC01322 (Long intergenic non-protein coding RNA 1322) is a long intergenic non-coding RNA (lincRNA) located on chromosome 3, also referred to as RNA upstream of Slitrk3 (RUS)[1][2]. It does not code for a protein but is thought to regulate gene expression through chromatin remodeling, transcriptional regulation, and modulation of neighboring genes, potentially affecting neurogenesis and tumor progression[2][3]. LINC01322 expression is dysregulated in various cancers, including renal cell carcinoma, lung cancer, and bladder cancer, where it may act as a prognostic and diagnostic biomarker[2]. It has been implicated in tumor microenvironment regulation, particularly through interactions that may involve the VHL gene in RCC, affecting extracellular matrix processes and possibly impacting cancer growth and metastasis[2]. Direct drug- or ligand-based therapeutic targeting has not been established, and its principal medical relevance currently lies in biomarker research rather than as a classical therapeutic target such as a receptor or enzyme[2][3].

Other names

RUSRNA upstream of Slitrk3LINC01322