Long intergenic non-protein coding RNA 1330 (LINC01330)

LINC01330 (Long intergenic non-protein coding RNA 1330), also referred to as LRRC77P, is classified as a unitary pseudogene and a long non-coding RNA (lncRNA) located on chromosome 3q26.1-q26.2[9][2]. It does not encode a protein and is not a classical receptor, enzyme, transporter, or transcription factor. There are no established biological functions or disease roles reported for this specific RNA; its functions remain largely unknown and it is not considered a therapeutic target, nor are any drugs known to interact with it[1][6][9]. Pseudogenes like LRRC77P may arise from ancestral protein-coding genes but generally lack functional biological activity. While many lncRNAs, including some from the LINC family, have emerging roles in regulating gene expression and potentially in disease processes such as cancer[4], there is currently no published evidence implicating LINC01330/LRRC77P in specific biological pathways or disease roles, nor information on its utility as a biomarker or its safety profile. Notably, the dual naming and pseudogene status point to ambiguity and indicate that LRRC77P/LINC01330 is not a well-characterized molecular target. Structured biomedical databases such as HGNC and Monarch Initiative provide only basic annotation, without supporting evidence for clinical or mechanistic significance[9][7]. Thus, querying LRRC77P as a receptor or canonical therapeutic target is **incorrect**. The entry is better classified as a non-functional or uncharacterized long non-coding RNA pseudogene.

Other names

LRRC77Plong intergenic non-protein coding RNA 1330LINC01330RP11-298O21.5