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Long intergenic non-protein coding RNA 1356 (LINC01356)
- Target
- LINC01356
- Molecular classification
- Other (Long intergenic non-coding RNA, lincRNA)
01
Overview
Long intergenic non-protein coding RNA 1356 (LINC01356) is a cytoplasm-localized long intergenic non-coding RNA (lincRNA) with elevated expression in certain cancer cell lines, exosomes, and in the plasma of patients with brain metastasis from lung cancer[2][4]. Experimental studies indicate that exosomal LINC01356 can regulate blood-brain barrier permeability, possibly by downregulating tight junction and adhesion proteins (including Occludin, Claudin-5, and N-cadherin), thereby enhancing the ability of cancer cells to cross the BBB and seed brain metastases[4]. LINC01356 also exhibits cell-type specific expression in pluripotent stem cells, suggesting context-dependent biological functions[2]. While it is not a protein-coding receptor, enzyme, or classic therapeutic target, it may serve as a biomarker for metastatic potential and as a modulator of cell signaling in the tumor microenvironment[2][4].
- Other names
- LIMp27Long noncoding RNA inhibiting the mRNA of p27Putative uncharacterized protein encoded by LINC01356
02
Biological functions
Regulation of blood-brain barrier (BBB) permeabilityCell-to-cell signaling via exosomesMay influence cell junction and adhesion protein expressionLikely contributes to cell proliferation or migration in the context of cancer
03
Disease associations
Cancer (notably lung cancer brain metastasis)Possibly other roles in stem cell differentiation and lineage commitment
04
Biomarkers
Exosomal LINC01356 in plasma as a potential biomarker for brain metastasis in lung cancer[4]
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