Long intergenic non-protein coding RNA 1359 (LINC01359)

Long intergenic non-protein coding RNA 1359 (LINC01359) is a long intergenic non-coding RNA (lincRNA), defined as an autonomously transcribed RNA longer than 200 nucleotides that does not overlap with protein-coding genes. LINC01359, like other lincRNAs, does not encode a protein but may function in gene regulatory processes such as chromatin remodeling, fine-tuning the expression of adjacent genes, and influencing tissue-specific gene networks. While most biological functions of LINC01359 remain to be fully elucidated, lincRNAs as a molecular class play important roles in normal physiology, gene regulation, and diseases (notably various cancers). LINC01359 in particular has been reported to be associated with immune cell-related signatures in certain cancer studies; however, there are currently no approved drugs targeting it, nor is it a recognized therapeutic target. Key context and supporting details: - LINC01359 is listed as a long non-coding RNA gene in relevant genomics databases, including GeneCards, under the full name "Long intergenic non-protein coding RNA 1359"[1]. - LincRNAs (long intergenic non-coding RNAs) are a subclass of long non-coding RNAs, generally over 200 nucleotides, and do not overlap protein-coding genes[3][5][7]. - They can regulate gene expression at multiple levels, sometimes in cis (locally) or in trans (distant), act as molecular scaffolds for chromatin-modifying complexes, or influence cell type–specific transcriptional programs[3][5][7]. - While many lincRNAs are being studied for their disease roles, only a minority have well-established direct functions; for LINC01359, the literature indicates putative association with immune infiltrates in cancer but not a validated therapeutic or biomarker role[4]. - There are currently no drugs targeting LINC01359, and it is not categorized as an enzyme, transporter, receptor, or similar canonical drug target; its primary molecular classification is as a non-coding RNA[1][4][7].

Other names

LINC01359