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Long intergenic non-protein coding RNA 1366 (LINC01366)
- Target
- LINC01366
- Molecular classification
- Long non-coding RNA (lncRNA), Other (not a receptor, enzyme, transporter, or transcription factor; specifically classified as a regulatory non-coding RNA)
01
Overview
Long intergenic non-protein coding RNA 1366 (LINC01366) is a lncRNA located on chromosome 5 (coordinates: 170,306,810–170,335,508), implicated in the regulation of gene networks relevant to cancer biology, especially glioblastoma multiforme[7]. Emerging research suggests LINC01366 is upregulated in glioblastoma and thyroid carcinoma, and may regulate inflammation and angiogenesis by acting as a competing endogenous RNA (ceRNA) affecting RELA (NF-κB subunit)[2][6]. Its specific molecular mechanisms and therapeutic relevance remain under active investigation, but it is considered a promising candidate for further research as a diagnostic marker and therapeutic target in oncology[2]. No drugs are currently approved to target LINC01366 directly.
- Other names
- CTB-114C7.3LINC01366
02
Biological functions
Gene regulation via ceRNA network (competing endogenous RNA)Regulation of transcription factors (including interaction with RELA/NF-κB)Putative regulation of inflammation and angiogenesisModulation of autophagyPossibly cell proliferation and cancer progression
03
Disease associations
Cancer (notably glioblastoma multiforme, thyroid carcinoma; upregulated in these malignancies)InflammationAngiogenesis-related processes in tumor biology
04
Biomarkers
High expression of LINC01366 may serve as a biomarker for glioblastoma multiforme and possibly other cancers, indicating disease progression or future diagnostic utility
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