Long intergenic non-protein coding RNA 1370 (LINC01370)

Long intergenic non-protein coding RNA 1370 (LINC01370) is a human long non-coding RNA gene, part of the long intergenic non-coding RNA (lincRNA) class, and is affiliated with the broader lncRNA family[1][7][8][9]. It is sometimes referred to as HI-LNC25 or Human Islet Long Non Coding RNA 25[2][8]. LINC01370 is located at chromosomal locus 20q12. LincRNAs are characterized by transcripts greater than 200 nucleotides that do not overlap protein-coding genes and play diverse regulatory roles, often affecting chromatin architecture, transcriptional regulation, or serving as molecular scaffolds[3][5]. In the context of islet biology, LINC01370 is enriched in human pancreatic islets and has been implicated in the regulation of the gene GLIS3, a transcription factor essential for β-cell development and insulin transcription[4][6]. Although direct disease mechanisms are still being investigated, LINC01370 has been associated with both type 1 and type 2 diabetes, suggesting a developmental or regulatory role in islet cell function[7][4][6]. No drugs directly target this non-coding RNA, and it is not generally considered a classical therapeutic target such as a receptor or enzyme.

Other names

HI-LNC25Human Islet Long Non Coding RNA 25HILNC25