Target intelligence / Profile preview

Long intergenic non-protein coding RNA 1392 (LINC01392)

Target
LINC01392
Molecular classification
Long intergenic non-coding RNA (lincRNA), Non-coding RNA
01

Overview

Long intergenic non-protein coding RNA 1392 (LINC01392) is part of the lincRNA class, which includes large, autonomously transcribed RNA molecules that do not encode proteins and are generally located in gene deserts—regions of the genome not overlapping annotated protein-coding genes[1][3][5]. LincRNAs such as LINC01392 can fine-tune gene expression, influence chromatin architecture, and participate in regulatory processes both near their genomic loci (cis) or at distant sites (trans)[5][7][9]. While the broader lincRNA group is increasingly recognized for regulatory roles in cellular differentiation, cancer, metabolism, and neurological diseases[5][7][9], there is currently no direct functional or therapeutic evidence linking LINC01392 to specific diseases or drug responses in humans. Its primary biological significance is as a non-coding RNA locus identified in genetic association studies, rather than as an established therapeutic target or biomarker[1][6][10]. There is no evidence of misspelling or incorrect annotation for this target; however, it is important to note that LINC01392 is not a traditional therapeutic target such as a receptor, enzyme, transporter, or transcription factor. It serves as a regulatory non-coding RNA gene[3][5].

Other names
LINC01392
02

Biological functions

Regulation of gene expression as both cis and trans regulatorChromatin remodelingRNA stabilizationEpigenetic regulationPotential enhancer-associated activity
03

Disease associations

Association noted in genome-wide studies for obesity/adiposity traits in East Asian populations (potential biomarker or locus, not functionally validated)Closely located to variants associated with psychiatric traits and suicide attempt risk loci, but not directly implicated with functional evidenceNo direct functional or therapeutic association established with diseases
04

Biomarkers

LINC01392 has appeared as a locus in GWAS studies for obesity/adiposity in Asians[6][10], but not as a validated biomarker for patient selection or treatment monitoringNot currently used in clinical practice as a biomarker[1]

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