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Long intergenic non-protein coding RNA 1411 (LINC01411)
- Target
- LINC01411
- Molecular classification
- Long non-coding RNA (lncRNA), Intergenic lncRNA, Non-coding transcript
01
Overview
Long intergenic non-protein coding RNA 1411 (LINC01411) is a long non-coding RNA gene that does not encode a protein but is transcribed in specific human tissues. It belongs to the intergenic lncRNA class, meaning it is transcribed from regions between protein-coding genes. LINC01411 has been found to be among the most strongly upregulated lncRNAs in lesioned compared to preserved subchondral bone in osteoarthritis, and also shows differential expression in OA cartilage and synovium, suggesting a broad potential role in OA pathophysiology across joint tissues[4][8]. The precise function of LINC01411 remains unknown, but, like other lncRNAs, it may play roles in gene regulation, either at the transcriptional or post-transcriptional level, possibly influencing the expression of genes relevant to disease processes[2][4][8]. No interacting drugs, therapeutic mechanism of action, or well-documented safety concerns are currently known for this target.
- Other names
- RP11-267A15.1LINC01411
02
Biological functions
Regulation of gene expressionEpigenetic regulationPost-transcriptional regulationPotential involvement in cell-type specific gene expression (function not fully clarified)
03
Disease associations
Osteoarthritis (OA) (noted as highly upregulated in lesioned OA subchondral bone and differentially expressed in OA cartilage and synovium)Other (detection in GWAS studies, but no strong evidence for cancer or other diseases yet)
04
Biomarkers
May serve as a biomarker for osteoarthritis progression or affected tissues due to strong differential expression in OA versus healthy tissue
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