Long intergenic non-protein coding RNA 1423 (LINC01423)

LINC01423 (Long intergenic non-protein coding RNA 1423) is a long intergenic noncoding RNA found in the human genome. LINC01423 does not overlap any known protein coding genes and lacks protein coding potential. It has recently gained diagnostic relevance as a fusion partner with the ERG gene in pediatric B-cell precursor acute lymphoblastic leukemia, especially the “DUX4-rearranged” ALL subtype. Here, intrachromosomal rearrangements involve ERG and LINC01423, resulting in ERG-LINC01423 fusion transcripts that serve as indicators of underlying chromosomal deletions and alternative splicing events in leukemia subgroups. The precise biological function of LINC01423 is not well characterized, and it is not known to directly regulate cell signaling, apoptosis, or proliferation. No direct drug interactions or targeted therapies have been described, but its fusion products are increasingly recognized as relevant biomarkers for molecular stratification of leukemias. In summary: LINC01423 is a noncoding RNA whose main disease relevance relates to its role as a fusion partner in leukemia gene rearrangements. It is not a canonical drug target and lacks direct pharmacologic or functional interventions. Its diagnostic utility is in the molecular classification of pediatric ALL subtypes.

Not applicable; no known drugs target LINC01423 directly