Long intergenic non-protein coding RNA 1426 (LINC01426)

Long intergenic non-protein coding RNA 1426 (LINC01426) is a long non-coding RNA located on chromosome 12, with no protein-coding capability. It functions as an oncogenic lncRNA in several human cancers, most notably lung adenocarcinoma, where it is consistently upregulated in tumor tissues[1][2][3]. Functional studies indicate that LINC01426 promotes cancer cell proliferation, migration, invasion, stemness, and epithelial–mesenchymal transition. Mechanistically, LINC01426 interacts with microRNAs as a competitive endogenous RNA (for example, binding hsa-miR-30b-3p and miR-125a-5p), regulates protein partners such as AZGP1 and USP22, and activates oncogenic signaling (e.g., Hedgehog pathway via SHH stabilization)[1][2][3]. High expression of LINC01426 is associated with poor prognosis and advanced tumor stage, supporting its utility as a diagnostic and prognostic biomarker for lung adenocarcinoma and potentially other cancers. While there are no known direct interacting drugs, its regulatory functions make it a candidate for future targeted therapies, though challenges in targeting lncRNAs remain significant[1][2][3][5].

Other names

lincRNA-uc002yug.2LINC01426

Not directly targeted by approved drugs; instead, acts as a ceRNA (sponging microRNAs such as hsa-miR-30b-3p, miR-125a-5p), influences gene regulation through protein interaction (e.g. AZGP1, USP22), stabilizes downstream effectors in oncogenic pathways (e.g., Hedgehog pathway via SHH stabilization)[1][2][3]