Long intergenic non-protein coding RNA 1433 (LINC01433)

Long intergenic non-protein coding RNA 1433 (LINC01433) is a long non-coding RNA transcribed from chromosome 20p13 that does not encode a protein but plays important regulatory roles in gene expression[1][3]. LINC01433 is upregulated in several cancers, including glioblastoma multiforme, non-small cell lung cancer, breast cancer, gastric cancer, and nasopharyngeal carcinoma[2][3]. Its overexpression in cancer cells is associated with increased proliferation, migration, invasion, and promotion of epithelial–mesenchymal transition, suggesting an oncogene-like effect[2][3]. In glioblastoma, LINC01433 may act as a regulator of the RELA gene and is implicated in inflammation and angiogenesis pathways[2]. High levels of LINC01433 are linked to tumor progression and poorer prognosis, making it a potential prognostic biomarker in multiple cancers[3][4]. No direct drugs or targeted therapies are currently known, and there is still limited information on its safety profile as a therapeutic target, though its involvement in tumorigenesis suggests possible safety concerns if targeted[2][3].

Other names

LOC728228hCG2045830LINC01433