Long intergenic non-protein coding RNA 1435 (LINC01435)

Long intergenic non-protein coding RNA 1435 (LINC01435) is a human long non-coding RNA (lncRNA) located in an intergenic region and does not encode a protein[1][2]. It is not a protein, enzyme, receptor, transporter, or typical therapeutic target, but rather an intergenic lncRNA, part of the lincRNA subclass[1][5]. LINC01435 functions primarily as a regulator of gene expression at the transcriptional level, notably through chromatin remodeling and regulation of transcription[2]. In the context of diabetic wound healing, LINC01435 is delivered via exosomes from keratinocytes to vascular endothelial cells, where it upregulates histone deacetylase 8 (HDAC8) expression by recruiting the transcription factor YY1 into the nucleus[2]. This interaction leads to the suppression of endothelial cell migration and angiogenesis, thereby interfering with proper tissue repair in diabetic wounds. Its regulatory role and involvement in disease pathology make it a molecule of interest in understanding wound healing and possibly other vascular or inflammatory conditions[2][5]. Currently, there are no approved drugs or established biomarkers directly targeting or using LINC01435, and no specific safety or pharmacological concerns have been noted in the literature[2][5].

Other names

RP11-215N21.1TCONS_00018040LINC01435