Target intelligence / Profile preview

Long intergenic non-protein coding RNA 1445 (LINC01445)

Target
LINC01445
Molecular classification
Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA)
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Overview

LINC01445 (long intergenic non-protein coding RNA 1445) is a long intergenic non-coding RNA (lincRNA), which means it is a transcribed RNA molecule longer than 200 nucleotides and does not encode a protein. LincRNAs like LINC01445 are distinguished by their lack of protein-coding ability and their location outside of known protein-coding gene loci. As a member of the lncRNA transcript family, LINC01445 might participate in various regulatory functions such as chromatin and nuclear architecture remodeling, transcriptional regulation (acting locally or at a distance), and the modulation of gene expression with tissue specificity. However, the biological significance and precise tissue, cellular, or disease roles of LINC01445 itself remain uncharacterized in public reference databases and most peer-reviewed literature. Most lincRNAs, including LINC01445, are still under study for their functional relevance in cellular physiology and pathology.

Other names
LINC01445Long intergenic non-protein coding RNA 1445
02

Mechanism of action

Not applicable, since no drugs are known to target LINC01445.

03

Biological functions

Chromatin remodelingGenome architecture regulationTranscriptional regulation (cis and trans)Fine-tuning expression of neighboring genesRNA stabilization

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