Long intergenic non-protein coding RNA 1465 (LINC01465)

Long intergenic non-protein coding RNA 1465 (LINC01465) is a member of the lincRNA subclass of long non-coding RNAs, which are defined as regulatory RNA transcripts longer than 200 nucleotides that do not overlap with coding genes[1][5]. LINC01465 is located on chromosome 12q14.1 and has been detected at high levels in specific epithelial ovarian cancer (EOC) cell lines, where it may influence cancer cell migration and survival[2][4]. Silencing LINC01465 in cancer models reduces migration and modifies drug response, suggesting a role in gene expression networks governing tumor cell behavior. While it is not a classical therapeutic target such as a receptor or enzyme, LINC01465 and related lincRNAs attract attention for their regulatory functions and as potential diagnostic or prognostic biomarkers, especially in oncology[1][2][3][5]. The precise molecular mechanisms and broader biological implications of LINC01465 remain under investigation.

Other names

LINC01465C12orf61FLJ25590Putative uncharacterized protein encoded by LINC01465

Not established as a direct drug target; may mediate drug response or resistance by regulating gene networks influencing cell death or migration