Long intergenic non-protein coding RNA 1473 (LINC01473)

Long intergenic non-protein coding RNA 1473 (LINC01473) is a long non-coding RNA (lncRNA), meaning it does not code for a protein product but functions at the RNA level. LINC01473 has been identified as differentially expressed in osteoblasts from patients with multiple myeloma compared to healthy controls, where its expression is upregulated. The biological role of LINC01473 remains largely uncharacterized, but preliminary research suggests it may be involved in regulating gene expression related to osteoblast activity and bone disease. Specifically, LINC01473 has shown co-expression with the mRNA of CD74—a gene implicated in immune response and bone remodeling—hinting at a potential regulatory function. Its altered expression may participate in the disrupted bone formation and immune evasion observed in multiple myeloma, but direct molecular mechanisms or validated therapeutic targeting have not yet been established.

Other names

LINC01473long intergenic non-coding RNA 1473