Long intergenic non-protein coding RNA 1480 (LINC01480)

Long intergenic non-protein coding RNA 1480 (LINC01480) is a long non-coding RNA identified as a hub gene correlating with immune cell infiltration in coronary artery disease and ischemic cardiomyopathy. Upregulation of LINC01480 is associated with protective roles, notably promoting M2 macrophage populations, which have anti-inflammatory effects in cardiac tissues. It is also implicated in regulating immune pathways and metabolic signaling, including downregulation of the mTOR and insulin pathways, suggesting a complex role in cardiovascular and metabolic disease pathogenesis. LINC01480’s expression stratifies cardiovascular disease patients and correlates with cancer immune microenvironments, making it a candidate biomarker and potential therapeutic target. However, no direct drug interactions are documented, and further clinical and experimental validation is required before therapeutic application.

Other names

LINC01480

Modulates immune cell infiltration, potentially protecting against disease progression by increasing anti-inflammatory M2 macrophages. Downregulates mTOR and insulin signaling pathways, which may reduce risk of metabolic complications.