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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1508 (LINC01508)
- Target
- LINC01508
- Molecular classification
- Long non-coding RNA, Intergenic lncRNA, Non-protein coding RNA
01
Overview
Long intergenic non-protein coding RNA 1508 (LINC01508) is an intergenic, long non-coding RNA located on chromosome 9q22.2 and is comprised of 1,030 nucleotides. LINC01508 acts as a regulatory molecule in cancer cells, particularly ovarian and breast cancer, where its expression is linked to cellular sensitivity and resistance to platinum-based chemotherapy such as cisplatin. Downregulation of LINC01508 is correlated with increased cisplatin resistance and poorer prognosis, while upregulation enhances sensitivity by suppressing the Hippo-YAP signaling pathway. LINC01508 is under evaluation as a potential therapeutic target and biomarker for response prediction and prognosis in cancer.
- Other names
- LINC01508
02
Mechanism of action
Modulation of cellular sensitivity to cisplatin through suppression of the Hippo-YAP pathway\nPutative regulatory control of tumor cell growth and viability under chemotherapy
03
Biological functions
Regulation of cell proliferationRegulation of chemotherapy sensitivity (notably cisplatin)Modulation of Hippo-YAP signaling pathwayPrognostic biomarker (e.g., overall survival in cancer)
04
Disease associations
Cancer (Ovarian, Breast; linked to platinum and chemotherapy resistance)
05
Safety considerations
Therapeutic targeting of lncRNAs such as LINC01508 is experimental; safety in humans is undeterminedSpecific off-target effects and delivery challenges are potential concerns for lncRNA-directed therapies (general, not LINC01508-specific)
06
Interacting drugs
Cisplatin
1 more in the full profile.
07
Biomarkers
LINC01508 expression (prognostic for chemotherapy response and overall survival in cancer patients)
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