Long intergenic non-protein coding RNA 152 (CYTOR (alternatively LINC00152))

CYTOR (LINC00152) is a long non-coding RNA (lncRNA), approximately 828–852 base pairs, located on human chromosome 2p11.2, primarily expressed in the cytoplasm and occasionally in the nucleus. CYTOR acts as a competitive endogenous RNA (ceRNA), sponging microRNAs and interacting with chromatin-modifying complexes such as PRC2, thus regulating a wide variety of downstream genes and pathways critical for tumor progression, cell proliferation, invasion, EMT, and therapy resistance. It is overexpressed in many cancers and correlated with tumor aggressiveness and poor outcomes, serving as a promising biomarker and a potential (experimental) therapeutic target; no drugs are approved to target it, but antisense and RNA interference modalities are under investigation. Its incomplete conservation in model organisms presents challenges for translational research and therapeutic development.

Other names

CYTORLINC00152C2orf59NCRNA00152MGC4677Long intergenic non-protein coding RNA 152STAiR18

If targeted by drugs (e.g., by antisense oligonucleotides), mechanisms would chiefly involve: Inhibition of lncRNA function (e.g., interference with ceRNA/miRNA sponging, disruption of epigenetic modulation)