Long intergenic non-protein coding RNA 1522 (LINC01522)

LINC01522 (Long intergenic non-protein coding RNA 1522, also known as DRAIC or lnc152) is a human long intergenic non-coding RNA that does not encode a protein but regulates gene expression through various mechanisms. It is highly expressed in luminal and HER2 subtypes of breast cancer, where it acts as a tumor suppressor, attenuating cell migration, invasion, metastasis, and angiogenesis. LINC01522 interacts with key regulatory proteins such as RBM47 and impacts cancer progression, with expression differences offering potential utility as a biomarker in cancer diagnosis and prognosis. The functional significance and possible therapeutic targeting of lincRNAs like LINC01522 is an active field of research in cancer biology.

Other names

DRAIClncRNA152lnc152

Experimental knockdown (siRNA-based) or overexpression alters cancer cell invasion, migration, proliferation, and angiogenesis. Mechanisms include upregulation or stabilization of tumor suppressor proteins (e.g., RBM47), interference with protein translation, and modulation of gene expression programs involved in cancer biology.