Long intergenic non-protein coding RNA 1537 (LINC01537)

LINC01537 (long intergenic non-protein coding RNA 1537) is a cytoplasmic long non-coding RNA involved in post-transcriptional gene regulation, particularly by stabilizing PDE2A mRNA through RNA–RNA interaction. It acts as a tumor suppressor in lung cancer, inhibiting cell proliferation, migration, and promoting apoptosis. LINC01537 is downregulated in lung cancer and its overexpression suppresses tumor growth both in vitro and in vivo. It plays a role in regulating cellular energy metabolism, notably mitochondrial respiration and glycolysis. The expression level of LINC01537 serves as a prognostic biomarker for cancer survival, and LINC01537 may sensitize tumors to certain therapies like nilotinib by altering metabolic pathways. These properties highlight LINC01537 as a promising candidate for cancer prognosis and as a potential therapeutic RNA target.

Other names

RP11-169D4.1-001LINC01537

Drugs targeting the LINC01537/PDE2A axis may work by interfering with the lncRNA's stabilization of PDE2A mRNA, affecting cancer cell metabolism and growth. Nilotinib: increased sensitivity via modulation of tumor metabolism and apoptosis.