Long intergenic non-protein coding RNA 1546 (LINC01546)

Long intergenic non-protein coding RNA 1546 (LINC01546, also known as VAL or CXorf28) is a cytoplasmic lncRNA directly induced by AKT/STAT3 signaling and essential for tumor dissemination in lung adenocarcinoma. Unlike other lncRNAs that drive epithelial-mesenchymal transition, VAL mediates metastasis independently of EMT by binding Vimentin and preventing its TRIM16-mediated polyubiquitination and degradation. This results in stabilization of Vimentin, increased cell invasiveness, and resistance to anoikis. VAL is undetectable in some mesenchymal cells, suggesting cell-type specific effects, and is directly correlated with poor patient prognosis and cancer progression. RNA interference targeting VAL presents therapeutic potential, and VAL/Vimentin pathway components may serve as both biomarkers and drug targets in aggressive cancer[1][2][4][5].

Other names

Vimentin associated lncRNA (VAL)CXorf28Putative uncharacterized protein encoded by LINC01546

siRNAs or antagonists suppress metastasis by reducing VAL expression; Inhibiting VAL restores Vimentin degradation via the Trim16 E3 ligase pathway, consequently reversing invasive cancer phenotypes