long intergenic non-protein coding RNA 1568 (LINC01568)

long intergenic non-protein coding RNA 1568 (abbreviated as LINC01568 and also known as LOHAN2) is a human long non-coding RNA (lncRNA) gene located on chromosome 16[1][2][9]. It is named for its upregulation and potential oncogenic function in head and neck cancers[1][7]. lncRNAs like LINC01568 typically do not encode proteins but participate in regulating gene expression at transcriptional and post-transcriptional levels. In cancer contexts, certain lncRNAs act as oncogenes, promoting tumor growth, proliferation, migration, and metastasis. Although many lncRNAs (including LINC01568) are emerging as therapeutic targets and potential biomarkers in oncology—especially in head and neck malignancies—the precise molecular mechanisms and validated therapeutic interventions for LOHAN2/LINC01568 remain under current investigation[5][7][9][10].

Other names

lncRNA oncogene in head and neck cancer 2LOHAN2LINC01568

General mechanisms targeting lncRNAs include RNA interference (e.g., siRNA, antisense oligonucleotides) and nonspecific effects of chemotherapies that modulate lncRNA expression in cancer cells