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Long intergenic non-protein coding RNA 1588 (LINC01588)
- Target
- LINC01588
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-protein coding RNA (lincRNA)
01
Overview
Long intergenic non-protein coding RNA 1588 (LINC01588) is a member of the lncRNA class, specifically classified as a lincRNA, which is transcribed from regions of the genome that do not overlap protein-coding genes. It does not encode a protein and is implicated in non-coding RNA-mediated gene regulation. LINC01588 is annotated in major databases and is associated with L-2-hydroxyglutaric aciduria, and has been reported to regulate WWP2-mediated cardiomyocyte injury via interaction with HNRNPL. There is no evidence currently that LINC01588 is directly druggable or acts as a classical therapeutic target; however, lincRNAs as a group have emerging roles in complex diseases, cell regulation, and diagnostics[1][2][3][5][6][7][9].
- Other names
- C14orf182LINC01588C14orf183LINC01599THE1B/LINC01599
02
Mechanism of action
Not applicable; there are no drugs with specific mechanisms of action targeting LINC01588 as of current knowledge
03
Biological functions
Gene regulation (interacts with chromatin, transcriptional machinery, or RNA-binding proteins)Regulation of cellular response to stress or injury (e.g., cardiomyocyte injury via WWP2-HNRNPL interaction)Epigenetic regulation (general lncRNA property)Regulation of cell differentiation, cell cycle, and development (lncRNA/lincRNA function in general)
04
Disease associations
L-2-Hydroxyglutaric aciduria (reported association)Cardiomyocyte injury/regulation (through interaction with WWP2 and HNRNPL)Cancer and other complex diseases (general lincRNA association; no specific linkage for LINC01588 yet)
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