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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1589 (LINC01589)
- Target
- LINC01589
- Molecular classification
- Long non-coding RNA, Long intergenic non-coding RNA (lincRNA), Other
01
Overview
Long intergenic non-protein coding RNA 1589 (LINC01589) is a member of the long intergenic non-coding RNA (lincRNA) family, which are non-coding RNA transcripts greater than 200 nucleotides in length that do not overlap with annotated protein-coding genes[1][3]. LINC01589 is expressed in human tissues and has been implicated as a tumor suppressor and immune regulator, with higher levels correlating with better outcomes in patients with uterine corpus endometrial carcinoma (UCEC)[4]. Genes coexpressed with LINC01589 are enriched in processes related to nervous system development and immune response, and its expression is associated with increased levels of immune cell infiltration including B cells, T cells, natural killer cells, and dendritic cells[4]. Low levels of LINC01589 predict worse clinical outcomes in UCEC, suggesting it may serve as a prognostic biomarker but is not a druggable therapeutic target or traditional receptor/enzyme[4][1]. Overall, LINC01589 influences tumor biology and immunity primarily via gene regulation mechanisms typical of long non-coding RNAs.
- Other names
- CTA-941F9.9TCONS_00029353LINC01589
02
Biological functions
Gene expression regulationChromatin remodelingImmune regulationCell differentiationTumor suppression
03
Disease associations
Cancer (notably endometrial carcinoma, based on reported tumor suppressor activity and correlation with clinical outcomes)Possibly other diseases through gene regulation, but cancer is the best established
04
Biomarkers
Potential prognostic biomarker for uterine corpus endometrial carcinoma (UCEC), especially for overall survival and clinical outcome prediction
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