Long intergenic non-protein coding RNA 1592 (LINC01592)

Long intergenic non-protein coding RNA 1592 (LINC01592) is a long intergenic non-coding RNA (lincRNA) identified in humans. It is not a protein or receptor; rather, it is a regulatory non-coding RNA molecule that can bind and modulate the activity and nuclear localization of the transcription factor E2F6. In esophageal cancer, LINC01592—delivered to tumor cells by exosomes from M2 tumor-associated macrophages—promotes immune evasion by upregulating NBR1 transcription via E2F6, which leads to enhanced degradation of MHC-I on tumor cell surfaces and impairs CD8+ T cell-mediated antitumor responses. Its function is mostly characterized in the cancer immunology context, and there are currently no drugs known to target or modulate LINC01592 directly. The gene is classified as a long non-coding RNA and is not generally considered a canonical "therapeutic target" such as a receptor, enzyme, ion channel, or signaling protein, though it could be considered a potential *biomarker* or *target for future RNA-based therapeutics* due to its disease-promoting roles[1][2][3].

Other names

LINC01592long intergenic non-protein coding RNA 1592