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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1594 (LINC01594)
- Target
- LINC01594
- Molecular classification
- Long noncoding RNA (lncRNA), Non-protein coding RNA, Other
01
Overview
Long intergenic non-protein coding RNA 1594 (LINC01594) is a type of long noncoding RNA that does not code for proteins. It is significantly upregulated in colorectal cancer and is associated with poor prognosis. Mechanistically, LINC01594 acts as a scaffold for the enzyme DNMT1, leading to increased methylation of the CELF6 promoter and reduced CELF6 expression. LINC01594 also competitively binds to the transcription factor p53, further decreasing CELF6 levels. This regulatory cascade inhibits CELF6-mediated exon skipping of CD44, a process implicated in cancer metastasis. Thus, LINC01594 contributes to tumor progression and metastasis and is under investigation as a novel biomarker and potential therapeutic target for colorectal cancer.
- Other names
- LINC01594TCONS_l2_00015893
02
Biological functions
Gene regulation (epigenetic modification via DNA methylation)Interaction with transcription factors (e.g., competitive binding with p53)Alternative splicing regulation (of CELF6-mediated CD44 exon skipping)Promotion of cell metastasis (in colorectal cancer)
03
Disease associations
Cancer (most notably colorectal cancer)Other (potential unknowns; current research focuses on CRC)
04
Biomarkers
LINC01594 expression (as a prognostic biomarker for poor prognosis in CRC)The LINC01594–CELF6–CD44 axis (potential biomarker pathway for CRC metastasis)
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