Long intergenic non-protein coding RNA 1620 (LINC01620)

Long intergenic non-protein coding RNA 1620 (LINC01620) is a human long non-coding RNA (lncRNA) belonging to the class of long intergenic non-coding RNAs that do not encode a protein and are situated in genomic regions that do not overlap protein-coding genes. It has been identified by several aliases including dJ1013A22.3, C20orf62, lncRNA-DAW, and Distant Activator of Wnt2. While comprehensive functional studies are lacking, current evidence and database entries suggest that LINC01620 may play roles in transcriptional and epigenetic regulation, and by its alias "Distant Activator of Wnt2", it is inferred to have regulatory influence over WNT2 gene expression, which itself is implicated in cancer and several signal transduction pathways[1][5][9]. LINC01620 is a non-protein-coding gene based on database definitions and has no known protein product or direct receptor/enzyme/transporter activity[1]. Long intergenic non-coding RNAs (lincRNAs) are typically involved in regulation of gene expression, often at the epigenetic or transcriptional level, sometimes modulating the expression of nearby or distant protein-coding genes[5][9]. The alias "Distant Activator of Wnt2" and "lncRNA-DAW" suggests a specific potential function in the regulation of WNT2, a gene involved in Wnt signaling pathway and cancer-related processes[1]. No direct evidence currently supports its action as a classic drug target, receptor, or enzyme, nor are there known drugs that modulate its function. There is presently no indication that LINC01620 itself is a direct therapeutic target, and there are no drugs, mechanisms of action, biomarkers, or safety concerns specifically associated with this lncRNA.

Other names

dJ1013A22.3C20orf62uncharacterized protein C20orf62lncRNA-DAWDistant Activator of Wnt2LINC01430