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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1627 (LINC01627)
- Target
- LINC01627
- Molecular classification
- long non-coding RNA (lncRNA), Other
01
Overview
Long intergenic non-protein coding RNA 1627 (LINC01627) is a long non-coding RNA belonging to the lncRNA class. It shows elevated expression in epithelial ovarian cancer tissues relative to normal tissue, and higher levels are associated with poor prognosis, particularly in high-grade, advanced, and serous subtypes. Experimental knockdown in ovarian cancer cell lines reduces cell proliferation and migration, indicating an oncogenic role. Meta-analysis supports its prognostic value. LINC01627 may represent a candidate biomarker and therapeutic target in ovarian cancer, though its precise molecular mechanism requires further research.
- Other names
- RP11-397D12.4LINC01627
02
Biological functions
Cell proliferationCell migrationCell cycle regulation
03
Disease associations
Cancer (especially high-grade, advanced, and serous epithelial ovarian cancer, and possibly non-small-cell lung cancer)
04
Safety considerations
No established safety concerns, but concerns may arise over specificity, delivery, and off-target effects if therapeutically targeted in the future.
05
Biomarkers
Expression level of LINC01627 may serve as a biomarker for cancer prognosis, notably in epithelial ovarian cancer
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