Long intergenic non-protein coding RNA 165 (LINC00165)

Long intergenic non-protein coding RNA 165 (LINC00165) is a member of the long non-coding RNA (lncRNA) family, specifically classified as a long intergenic non-coding RNA (lincRNA), meaning it is transcribed from genomic regions that do not overlap protein-coding genes. LINC00165 is upregulated in gastric cancer, where it promotes cancer cell proliferation, migration, and invasion, correlating with worse tumor stage and survival outcomes. Mechanistically, LINC00165 acts as a nuclear scaffold for the Polycomb Repressive Complex 2, supporting epigenetic regulation such as the epithelial-mesenchymal transition in cancer cells. Its expression is induced by the transcription factor STAT3. Although LINC00165 is associated with poor prognosis in gastric cancer and may have value as a biomarker, neither it nor its gene product is currently considered a therapeutic target, and there are no drugs directly targeting it as of the available evidence.

Other names

NLC1-BAP001505.9C21orf135NCRNA00165NLC1Bnarcolepsy candidate-region 1 gene Bnarcolepsy candidate region gene 1B

Not targeted by drugs; functions as scaffold for Polycomb Repressive Complex 2, mediates epigenetic regulation