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Long intergenic non-protein coding RNA 1654 (LINC01654) is a member of the long intergenic non-coding RNA (lincRNA) class, which includes autonomously transcribed RNA genes longer than 200 nucleotides that do not overlap protein-coding genes[1][5][3][9]. LINC01654 is transcribed from intergenic regions and does not encode a protein. The functions of lincRNAs, including LINC01654, generally involve chromatin remodeling, regulation of transcription, and fine-tuning the expression of neighboring genes; many act with remarkable tissue or even cell-type specificity[3][9]. Although the majority of lincRNAs remain uncharacterized with respect to disease or therapeutic targeting, the class is recognized for its roles in controlling gene regulatory networks and diverse biological processes[3][9]. There is no evidence that LINC01654 itself is a therapeutic target, nor are there any known drugs, biomarkers, or specific disease roles currently associated with this transcript[1][5].
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