Long intergenic non-protein coding RNA 1673 (LINC01673)

Long intergenic non-protein coding RNA 1673 (LINC01673) is a long non-coding RNA gene located on chromosome 17 that lacks protein-coding potential. It plays important regulatory roles in gene expression by epigenetically silencing tumor suppressor genes and modulating key signaling pathways associated with cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition. LINC01673 acts as a molecular scaffold and as a competing endogenous RNA, regulating microRNA activity in a tissue- and context-dependent manner. While LINC01673 promotes tumor progression in most cancers, it may function as a tumor suppressor in pancreatic cancer. Its elevated expression is considered a poor prognostic indicator for several malignancies, and its presence in peripheral blood positions it as a candidate biomarker for diagnostic and prognostic applications. No drugs are currently known to specifically target LINC01673, although its mechanistic involvement with epigenetic enzymes and regulator proteins suggests therapeutic opportunities.

Other names

LINC00673SRA-like non-coding RNASLNCRERRLR01

Regulation of tumor suppressor gene expression via recruitment of epigenetic repressors (e.g., EZH2, LSD1, DNMT1) leading to histone methylation and transcriptional silencing. Acting as a molecular sponge for microRNAs (miR-515-5p, miR-205, miR-150-5p, miR-504) to regulate target mRNA expression. Formation of scaffolds that influence signaling pathways (e.g., WNT/β-catenin, PI3K/AKT).