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Long intergenic non-protein coding RNA 1705 (LINC01705)
- Target
- LINC01705
- Molecular classification
- Long non-coding RNA (lncRNA), Competing endogenous RNA (ceRNA)
01
Overview
Long intergenic non-protein coding RNA 1705 (LINC01705) is a cytoplasm-enriched long non-coding RNA implicated in the progression of breast cancer. It acts as a competing endogenous RNA by sponging miR-186-5p, thereby regulating the expression of TPR, a protein involved in mitosis and cell proliferation. Overexpression of LINC01705 promotes migration, invasion, proliferation, and cell cycle progression of breast cancer cells, while downregulation inhibits these oncogenic processes and promotes apoptosis. LINC01705 is considered a regulatory factor and potential biomarker for breast cancer, but it is not reported to interact with any known drugs nor used as a therapeutic target as of current research.
- Other names
- ERLRTBUR1RP11-400N13.3EMT-related lncRNA in RPETGF-beta-upregulated lncRNA 1RP11-815M8.1LINC02257
02
Mechanism of action
Functions as a competing endogenous RNA (ceRNA), sponging miR-186-5p to regulate the expression of TPR (translocated promoter region, nuclear basket protein)
03
Biological functions
Regulation of cell migrationRegulation of cell invasionPromotion of cell proliferationRegulation of apoptosisCell cycle progressionPost-transcriptional regulation
04
Disease associations
Cancer (particularly breast cancer)
05
Safety considerations
No drug-based safety concerns or therapeutic challenges are reported, as LINC01705 is under preclinical investigation and not currently a direct drug targetGeneral concerns relate to its oncogenic function (upregulation may promote cancer growth and metastasis)
06
Biomarkers
LINC01705 expression (biomarker for breast cancer progression)miR-186-5p expression may also be relevant by interaction
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