Long intergenic non-protein coding RNA 1727 (LINC01727)

Long intergenic non-protein coding RNA 1727 (LINC01727) is a long non-coding RNA gene identified as a lincRNA located on chromosome 20 (chr20:21570138-21578028, hg38)[1][3][5]. It consists of at least two exons and displays no protein-coding potential based on multiple predictive algorithms and experimental datasets[1]. The RNA is classified as intergenic, meaning it is transcribed from genomic regions that do not overlap coding genes. LINC01727 is also referred to as IRENA (IFN-responsive nuclear NF-κB activator), but there are currently no linked scientific publications providing experimental evidence for its precise biological function, molecular mechanism, or involvement in human disease. Its nomenclature suggests presumed association with interferon response and activation of the NF-κB pathway, but direct functional data are lacking as of the latest database updates[1][3][5]. No interacting drugs, biomarker status, or safety/therapeutic considerations have been described in available references[1][3][5].

Other names

IRENAIFN-responsive nuclear factor-kappaB activatorENSG00000279082RP1-167O22.1lnc-PAX1-1:10